Sepsis: Staging and Potential Future Therapies (Colloquium

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Sepsis: Staging and Potential Future Therapies (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease)

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Variability in pathogenesis and complex pathophysiology often delay diagnosis and create significant challenges for clinical studies in this group of critically ill patients. Mainly for those reasons, there is no therapy approved so far to overcome the underlying immune dysregulation. This book provides an overview about the state of the art of sepsis diagnostics and potential future therapies. Chapter 1 focuses on the immunologic staging of sepsis-the key for successful treatment of the dysregulated hot response. Chapter 2 reveals similarities in the immune response in sepsis and cancer-opening new avenues for novel therapies. Chapter 3 introduces an important modulator of the immune response-the endogenous cannabinoid system and elucidates its role in organ dysfunction in sepsis. Facing the increasing bacterial resistance to classical antibiotics, Chapter 4 discusses two unique mechanisms to treat infection and inflammation in sepsis: iron chelation, and the sphingosine pathway. The authors, all experts in experimental and clinical sepsis research, seek to provide further understanding of the complexities of the immune response as the physiological basis for the development of new therapeutics in sepsis.
Country USA
Brand Morgan & Claypool
Manufacturer Morgan & Claypool
Binding Paperback
UnitCount 1
EANs 9781615047567
ReleaseDate 0000-00-00

Country	USA
Brand	Morgan & Claypool
Manufacturer	Morgan & Claypool
Binding	Paperback
UnitCount	1
EANs	9781615047567
ReleaseDate	0000-00-00

Sepsis: Staging and Potential Future Therapies (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease)